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[148] attempted to target the dimer-of-dimers interface of the carboxy-terminal binding protein (CtBP) interacting protein (CtIP) via an innovative stapled peptide-based approach, in which they found that the helical content upon hydrocarbon stapling showed a sharp increase and a higher ability to resist protease hydrolysis as only a slight effect on the steady state level of CtIP was observed in the cycloheximide (CHX) chase experiment

1994;348:607627.[PubMed] Hamassaki-Britto DE, Hermans-Borgmeyer I, Heinemann S, Hughes TE